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Only 3 4% of the dose was found in tissues 168 h post-dosing.
A strong linear correlation between the PPI signal and the contrast dose was found (r = 0.998).
The maximum tolerated dose was found be >60 mg/kg via intravenous administration.
The 10% replacement dose was found to be the better of the two amounts evaluated in this study.
8-OH-DPAT at the 0.3 mg/kg dose was found to cause a marked increase in the three parameters of locomotor activity.
In addition, that dose was found to be ineffective on agitation, tremor, tail stiffness and audiogenic seizures.
The most effective dose was found to be at 0.5 mg/kg, i.p., which was considered for further studies.
The low LET dose of the cosmic radiation was determined by 4 TLD stacks, and the total dose was found to be 795 ± 14 μSv/d.
Less than 1% of the applied dose remained in the stratum corneum and ∼6% of the dose was found in tissues.
Temperature had an effect on SMO and Bright-Edge 80 removal while adsorbent dose was found to influence the removal of SMO.
Furthermore, the effective dose was found to vary with delivery system, demonstrating the importance of biomaterial carrier properties in the delivery of recombinant proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com