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For each patient, effective dose was evaluated using standard coefficients referring to a generic reference individual.
Following the recommendations of Publication 103 of the ICRP [14], these absorbed doses were then sex-averaged and the effective dose was evaluated using the tissue weighting factors of Publication 60 of the ICRP [15].
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The association between the actual and calculated phenprocoumon doses was evaluated using Passing Bablok regression analysis.
Fixed dosing was evaluated using doses of 35, 70, 140, 210, and 315 mg which correspond to 0.5, 1, 2, 3, and 4.5 mg/kg dosing for a 70 kg subject.
The pharmacokinetic dose proportionality was evaluated using a power model with Cmax and the AUC for the dosing period (AUCτ) for luseogliflozin on Day 7. Pharmacodynamic variables included 24-h cumulative UGE, total UGE, and UGE rate in each collection period.
Dose response was evaluated using contrasts within the ANCOVA model framework.
Dose response western data was evaluated using a one-way ANOVA followed by a Dunnet's post-hoc test.
The dose of dialysis delivered was evaluated using a second-generation Kt/V equation by Daugirdas [ 16].
Both plans were optimized with the same planning parameters, and the dose quality of the plans was evaluated using dosimetrics.
The presence of an interaction between vasopressor dose variables and baseline SOFA was evaluated using an interaction term in three-variable logistic models (vasopressor variable, SOFA variable and vasopressor*SOFA variable).
To minimize differences in cumulative oxaliplatin dose between patients, oxaliplatin-induced neuropathy was evaluated using an oxaliplatin-specific scale during the 2-week period after completion of the sixth cycle of treatment.
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