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The maximum tolerated dose was established at 3700 mg m−2; dose-limiting toxicities in the form of urinary incontinence, visual disturbance, and anxiety were observed at the highest dose level (4900 mg m−2).
The MTD was 216 mg/m and the recommended phase 2 dose was established at 200 mg/m given IV at Days 1, 8, and 15 every 4 weeks.
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dose was established as the MTD after obtaining an unacceptable incidence rate of DLT at 600 mg b.i.d.
Maximum tolerated dose was established with the 3-h infusion at 30 mg per day and was not reached with the 24-h infusion.
An adequate teicoplanin loading dose was established in 112 patients.
The maximum acceptable dose for BPA was established at 50 μg kg−1 body weight day−1 by the US Environmental Protection Agency USEPAA) (1993) and the tolerable daily intake (TDI) of 50 μg kg−1 body weight day−1 established by the European Food Safety Authority (EFSA) (2006).
Dose-limiting toxicity was established at 400 mg/day and included asymptomatic grade 3 hyperlipasemia or grade 3 headache.
The maximum-tolerated dose (MTD) of indisulam was established at 800 mg m−2 when given as a one-hour infusion once every 3 weeks (Raymond et al, 2002).
The pharmacokinetic behaviour of vincristine in wild-type, Mdr1ab KO and Mdr1ab/Mrp1 TKO mice, 10 14 weeks of age, was established at a dose of 1 mg kg−1.
DLT was established at a ZD2767P dose of 18.63 mg m−2 ×3 administrations and MTD at 15.5 mg m−2 ×3 administrations.
The MTD was established at 400 mg twice daily with 1 dose-limiting toxicity (DLT) observed (pericardial effusion).
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