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Taking into consideration the contribution of 137Cs to gamma dose (usage of expanded activity index formula) may lead to exceeding the value of 1 in some cases.
Our achievement of MR imaging in animal with 100-fold lower dose usage than clinically used non-targeting agent DTPA is also likely due to improved pharmokinetic properties such as retention time and biodistribution.
We defined the dose usage of telmisartan and GW9662 as follows.
Daily dose usage was multiplied by the public price per unit to estimate daily cost.
The pharmacological studies, while having the advantage of directly targeting the brain, have major issues with dose usage.
However, we also found that the highest dose (5 μM) of BPIQ caused a significantly toxicity towards zebrafish larvae (data not shown), suggesting that the dose usage of BPIQ should be more careful when further applied for lung cancer chemotherapeutics.
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Moreover, as a result of widespread and large-dose usage of various antibiotics in clinical settings, multidrug-resistant strains are emerging, increasing the difficulty of treating such bacterial infections [3].
The main problem for ER (once-daily dosing) usage is the need to be administered in a higher daily dose due to a loss of bioavailability [ 32].
This dose and usage are the same as those in phase III studies in Western countries, where EMs comprise the majority of patients.
Cardwell et al (2014) focussed solely on low-dose aspirin usage while Walker et al (2012) analysed both the low-dose aspirin usage and high-dose aspirin usage.
Figure 3 shows the temporal pattern of low-dose corticosteroids usage from December 2002 to December 2005 in patient quartiles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com