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After the MTD has been reached, another 20 patients were enrolled at this dose to determine a preliminary overall response rate (ORR).
Control animals received a single injection of 213Bi-DOTATATE plus an excess of DOTATATE (10−6 M) i.v. via the tail vein (blocking dose) to determine the non-receptor-specific binding of 213Bi-DOTATATE.
Additionally, we did not vary the exposure time or dose to determine the threshold necessary for biofilm induction.
In the current study, we measured hASM levels attained within specific regions of the mouse CNS following infusion at this same dose to determine the tissue levels needed for the observed efficacy (n = 8).
Blood samples were collected in lithium heparin tubes after each apremilast dose to determine plasma apremilast concentrations.
The proportion of mice that died in each group was calculated and plotted against the dose to determine the median lethal dose (LD50).
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Total organic carbon (TOC) and simazine removals were investigated at different reagent doses to determine the experimental conditions yielding the highest removal of simazine and TOC.
Study limitations might include the short treatment duration, absence of assessments beyond 3 h post-dose to determine duration of effect, and the lack of an active comparator.
However, the study is testing only one dose of omega-3 instead of multiple doses to determine the dose response relationship.
A well-powered sample size and a multiple-arms design with different fixed doses to determine dose-dependent effects should be considered for future studies.
A similar study in the future should consider a multiple arms design with different fixed doses to determine dose-dependent effects.
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