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Table 1 gives an overview of reported dose thresholds.
Those limiting values are given in literature, e.g., dose thresholds given in the package insert for SIR-Spheres®; [8] or thresholds discussed and published in [9].
Table 1 Dose thresholds for lung, normal liver, and tumor according to [8] represented by T 1 and dose thresholds T 2 published and discussed in [9] T 1 T 2 D L 25 Gy 25 Gy D NL 70 Gy 40 Gy D T > 100 Gy > 100 Gy.
It also provides an explanation for low dose thresholds.
Inverse variance weighted piecewise polynomial regression models were used to estimate dose thresholds.
Remarkably, different genes from this group had different low dose thresholds for down-regulation.
Similar(31)
The corresponding dose threshold is determined by the LET of the bombarding radiation.
Sample detectors were systematically irradiated at fixed grid locations near the core of a 2 MW research reactor to determine their operational neutron dose threshold.
It was found that there is a dose threshold (~7 nC/cm), at which all the OTS SAMs are removed [6].
"Dose threshold is a very contentious issue in the radiation community," says radiation epidemiologist Roy Shore, research head at the Radiation Effects Research Foundation in Hiroshima.
Taken together, these data indicate that the CNS could be sensitive to heavy ions and that responses to HZE impact depend on the nature of the particle, the dose threshold and the time delay to develop biological processes.
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