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Artemisinin dimers were later synthesized for use as a single dose therapy for malaria in order to improve compliance.
As it has been the case for N. gonorrhoeae, the rapid development of resistance in M. genitalium highlights the fact that the era of single dose therapy for uncomplicated STIs is long past.
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Dr. Kieran said he had received "literally 1,000 calls from doctors around the country" asking about low-dose therapy for patients who had run out of treatments, and he said many doctors were trying it.
Background: The pharmacokinetic profile of azithromycin supports its use as single-dose therapy for uncomplicated acute otitis media (AOM) in children.
As azithromycin is an effective, well-tolerated, single-dose therapy for NGU and cervicitis it is administered presumptively in many clinical settings, exposing a significant proportion of symptomatic patients with M.genitalium to azithromycin.
In this context, the potential treating yaws with oral, single-dose therapy, for example, with azithromycin, should be explored.
These findings support the hypothesis that patients with GSTT1-null genotypes have reduced detoxification of therapeutic agents and, in the case of high-dose therapy for acute myelocytic leukaemia, worse outcomes.
The overall response rate (60%), median time to treatment failure (10 months) and median survival (26 months) achieved with this regimen is comparable to that of previous studies of high-dose therapy for metastatic disease.
Entolimod (CBLB502) is a Toll-like receptor 5 agonist currently in development by Cleveland BioLabs (http://www.cbiolabs.com) as a single-dose therapy for exposure to potentially lethal whole body irradiation during a nuclear disaster.
The estimated log kill for intermediate-dose therapy from CALGB #9082 was 6.5 logs, compared with 9 logs or greater for high-dose therapy.
Our patient had an Ig A nephropathy treated with low dose steroid therapy for only a short while (1 week).
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