Sentence examples for dose that increases from inspiring English sources

It has been suggested to administer magnesium as an initial IV bolus, followed by a continuous infusion at a dose that increases the serum level to ∼3.5 mmol/L [ 163].

The BMD was defined as the dose that increases the risk or probability of being "abnormal" by 5% over background.

In contrast to the 0.0 g/kg dose that increased the activity over time, animals administered the low dose (0.5 g/kg) demonstrated an initial high activity followed by a decline over time.

The investigation committee established that there was no evidence that the published β-blocker uptitration was really done. 3 4 Cardiologists might also hope that the 100 mg dose that increased mortality in the POISE trial might have been excessive and that commoner dosages such as metoprolol 25 mg three times a day instead might be beneficial rather than harmful.

The evaluation would also suggest the presence of small threshold doses that increase with increasing mass.

Differences between effective ghrelin doses that stimulate cells proliferation or survival and doses that increase cells migration can be explained by the fact that these different cellular activities are mediated by different cellular pathways.

Analgesic combinations have been used for many years to achieve greater efficacy, enabling the use of lower doses that increase the therapeutic effect (synergism), thus diminishing adverse effects [ 1].

As already mentioned, we found in our laboratory that Epi, when given during normothermia in doses that increased CO without affecting vascular resistance, gave rise to vasoconstriction (increased α-adrenoceptor response), but failed to elevate low CO (decreased β-adrenoceptor response) when given during hypothermia [ 6].

Macitentan and ACT-132577 are about 50- and 16-fold respectively, more selective for ETA receptors than for ETB receptors [ 10] and at macitentan doses that increase endothelin-1, it is thus expected that the ETA receptor will be fully blocked.

The recommended starting dose is 5 mg once daily, with a gradual dose titration that increases the daily dose in 5 mg increments each week to reach a maximum dose of 10 mg twice daily.

Overt hypothyroidism is classically treated using L-thyroxine; elderly patients require a low initial dose that is increased every 4 to 6 weeks until normalization of TSH levels.