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A dose that would previously have been acceptable becomes lethal.
In other words, once again, it is the dose that makes the poison.
"It's just like medicine: it's the dose that makes the poison".
But with 10 worms, we've ascertained a dose that does not cause symptoms.
Women using antidepressants to treat hot flashes typically take half the dose that is used for depression.
Freireich started her off with a dose that turned out to be too high, and she almost died.
He added, "It's certainly unusual that they'd be willing to consider approving a dose that had not been extensively studied".
To put this in context, radiation levels in Chernobyl's control room immediately after the explosion reached about 300 sieverts, a dose that proves lethal after just one minute.
"It's the dose that makes the poison," Dr. Langerman said, in paraphrasing the Renaissance physician Paracelsus.
(A mammogram involves 0.7 millisieverts, a dose that is doubled with a 3-D mammogram).
But, given at a dose that helps patients who have already formed polyps, the drug failed to keep them from developing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com