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These were GCP-compliant, single and multiple dose studies of PK/PD and tolerability in healthy volunteers and postmenopausal women.
There are no published fixed dose studies of olanzapine in patients with bipolar disorder that allow examination of dose relations.
The flexible dose studies of aripiprazole showed modest effect (Streim et al 2004; De Deyn et al 2005).
As the use of inotropic agents was aimed at a specific haemodynamic goal(s) and titrated accordingly, fixed dose studies of inotropes were excluded.
The results of fixed dose studies of olanzapine are mixed in regards to dose relationship but not inconsistent with our findings.
The procedures described in this study apply to 'tracer dose' studies of novel agents in cancer patients, which may be performed prior to conventional Phase I trials.
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The main study was an ascending dose study of three doses (5, 15, and 30 ng/kg/min) of study drug or placebo administered in sequential 1 h intervals (3 h total).
Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant.
The design was a single ascending dose study of the safety, pharmacokinetics and preliminary efficacy of adjunctive L-arginine infusion.
Normal C57BL/6J mice were injected intravitreally with the highest dose studied of Lodamin (300 µg; n = 10) or vehicle (n = 10) and tested 14 days after injection.
RM prepared garlic extracts and performed dose study of garlic extracts.
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