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Radiation dose, stage, size of tumor mass, and age of patient also strongly impacted survival time.
The long-term follow-up phase included infants vaccinated with hepatitis B vaccine and who concomitantly received HBIg at first dose stage up to collection of blood samples at year 20.
The failure of multiple investigational therapies to influence survival or to affect symptoms in HFpEF likely reflects heterogeneous case inclusion (including geographic variation in trial recruitment), suboptimal drug administration with regard to dose, stage or endophenotype of disease, or an incomplete conception of disease pathophysiology.
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In general, type of fertilizer, dose, stages and form of use are stipulated by an empirical way and are highly varying among the growers (Bermejillo and Filippini 2007).
After baseline echocardiography, dobutamine was infused at a starting dose of 5 μg/kg/min for 3 min followed by 10 μg/kg/min for 3 min (low-dose stage).
The study consisted of the following three treatment phases (Fig. 1): (1) The double- blind dose-confirmation phase was a 9-week, double-blind, randomized, placebo-controlled, parallel-group period consisting of a 3-week titration stage and a 6-week fixed-dose stage to confirm the effective dose range of MPH-LA.
Three arbitrary stages were used to guide initial bolus doses: stage 1, drowsy but easily rousable; stage 2, rousable with difficulty; and stage 3, unconscious on admission.
Sixty-four adults with primary AI started stage 1, and an additional 16 entered stage 3. Patients received DR-HC 20 40 mg once daily and hydrocortisone 20 40 mg divided into three daily doses (stage 1 only).
The study consisted of a single-dose, dose-escalation stage, followed by a randomized placebo-controlled, double-blind, parallel multidose stage.
In our previous pharmacokinetics studies in normal rats [ 18], ZMYL could produce a potential pharmacokinetics drug-herbs interaction on pharmacokinetic parameters of CDDP and plasma protein binding ratios in the early dosing stages (at 0.17, 0.33, 0.5, 1 h after dosing of CDDP).
Haematological indices, lactate dehydrogenase, dose level and disease stage were not significant.
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