Sentence examples for dose situation from inspiring English sources

However, the poor aqueous solubility of DCU poses a challenge for in vivo dosing in a multiple dose situation.

Due to ease of administration in a multiple dose situation, oral dosing of the nanosuspension was examined initially.

Formulation-based approaches to improve exposure to tool compounds, such as the addition of organic co-solvents, may interfere with the pharmacodynamic readout of the in vivo model or may not be tolerated if sustained systemic levels are required, as in the case of a multiple dose situation [2, 3].

Finally, our results apply to a single-dose situation, but relationships may change with long-term SGLT2 inhibition.

We conclude that the current practice of extrapolating the effects of high-dose exposures to lower-dose situations is unlikely to seriously underestimate radiation hazards for low LET radiation.

At 0.6 M. dose, the situation is reverse and the lowest scheme provides a better separation of the two model structures, in most of the realizations of all three cell types.

Concerning the dose-related situation, incubation of HUVECs for 1 h with various concentrations of OCN demonstrated that Akt phosphorylation and eNOS phosphorylation were gradually increased after treatment with 30, 60, 100, 150 ng/ml of OCN.

Notably, chronic, low-dose exposure situations produce 10- to 20-fold higher cadmium in kidney than liver.

We suggest that the signs of early renal injury and mild tubular impairment observed in chronic low-dose exposure situations viewed previously as benign could indeed be an early warning sign of subclinical or clinical morbidity and mortality.

A short text description providing information on the drug, dose and clinical situation was recorded for each error identified.

There is a growing interest in the assessment of the biological effects of low doses of IR, and particularly when they are delivered at low dose rate, a situation which is relevant to most environmental exposures.