The efficacy data were used to set doses for the 6-day repeat dose side effect study in rats.
Whole blood samples from the repeat dose side effect studies were collected in microtainer tubes containing lithium heparin via the vena cava prior to BALF collection or at the same time interval [21].
Methotrexate is the cornerstone of therapy in rheumatoid arthritis, and knowledge of dosing, side effects, teratogenicity, and monitoring are essential to its safe and effective use.
At high doses, side effects like drowsiness, dizziness and weight gain from retained water can limit its usefulness.
Medicinal poisoning, also called Drug Poisoning, harmful effects on health of certain therapeutic drugs, resulting either from overdose or from the sensitivity of specific body tissues to regular doses (side effects).
Background information, efficacy data, proposed mechanisms of action, recommended doses, side effects, and precautions are reviewed.
We recorded demographic data, indications for intensive care admission, paediatric index of mortality 2, duration of mechanical ventilation, length of stay, morphine and midazolam doses, clonidine indications and doses, side effects, efficacy and withdrawal symptoms.
This phase I study of high dose ketoconazole and docetaxel was designed against castration resistant prostate cancer to determine the maximum tolerated doses, side effects, and pharmacokinetic interaction of co-administered docetaxel and ketoconazole.
