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In an earlier study [23] we identified a difference in dose sensitivity for cocaine between the C57 and DBA strains; the latter strain having a dose-response curve shifted to the left.
First, early-life stages have increased dose sensitivity to most toxicants.
In addition to strong dose sensitivity, we observed interallelic rescue that is difficult to attribute solely to protein levels.
Although the shape of the Insl3 dose response is suggestive of low dose sensitivity, the difference was not significant.
Variation among the 15 trials was larger than expected (Q test: P=0.009), however, even for the high dose sensitivity analysis (Q test: P=0.006).
The lowest E2 dose tested, 400 pg/egg (40 ng/kg), sex reversed 14.4% of the animals, demonstrating very low dose sensitivity.
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The one-dose sensitivity trial with EB was performed using the bioassay methodology detailed in [ 54].
Since claudin-low cell lines and tumors preferentially express GLI1 transcripts, and claudin-low cells are transcriptionally similar to the JK184-sensitive EMT cells, we determined the dose-sensitivity of claudin-low cell lines to JK184.
Results of these studies indicate that members of the same family of miRs may work independently to execute normal physiologic functions and also explains that dose-sensitivity of miR-regulated proteins is involved in development and maintenance of normal cardiac physiology.
The aim was to characterize tissue-specific transcriptome responses and to identify potential in vivo biomarkers for (very) low mean absorbed doses with sensitivity to dose rate.
Ms. Valenti's other major initiative was a heavy dose of sensitivity training for employees, which she delivered in person.
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