The only exception is one of the low-dose samples of BI that clusters together with the high-dose sample of the same experiment.
Aliquots (20 ml) of pooled urine samples (0 24 h) from day 1 and day 3 were assayed for the 6β-hydroxycortisol : free cortisol ratio and compared with a day 1 pre-dose sample to look for evidence of CYP3A4 induction.
To estimate the enrichment of the dose sample, 0.00207 g of the dose sample was diluted with 0.99059 g of distilled water before analysis (Speakman, 1997).
Tumour concentrations of NVP-BEZ235 were measured in all of the acute single-dose samples with the exception of OCIP19, where insufficient material was available due to their small size.
Data abstracted were age, parity, smoking, duration of diabetes, pre-pregnancy planning, folic acid consumption, presence of microvascular complications, pre-pregnancy insulin dose, sample size, type of outcome or outcomes, main results, statistical methods and variables, if any, which were included in the adjusted model or models.
Complete data sets (pre-dose, 1 h post-dose and 24 h post-dose samples evaluable) of PBMC tubulin immunofluorescent staining were available for 19 patients.
Non-statistical data extracted included author, study location, study duration, perampanel dose, sample size, number/type of concomitant AEDs and seizure type at baseline.
The dendrogram shows a clustering of the low-dose samples with their untreated counterparts as well as a clustering of the high-dose samples.
We believe it was due to multiple factors including the frequency of image guidance, PTV margin and dose, sample size, and length of followup.
From the included studies the following information was abstracted: name of the first author, year of publication, duration of therapy, dose, sample sizes, change in MADRS and HAM-D total score from baseline, the number of patients with ≥ 50% decrease in MADRS and HAM-D total score, number of remitters and number of patients with adverse events.
In regard to the end-of-dose phenomenon, regulators usually will advise dense dose sampling especially at the end of each dosing interval.
