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9 Studies evaluating dose responsiveness have found a plateaued dose-response curve for PONV.
Analysis of the slopes of the AUC revealed that this was not a good parameter to use for analysis of dose responses, since these slopes were not significantly above 0, suggesting limited dose responsiveness in AHR to HDM exposure.
Mouse responsivity and discrimination threshold data to rat kairomones Dose responsiveness file: Dose responsiveness of mice (n=10) to differing volumes (ul) of rat urine (kairomone) or control (PBS).
This is in contrast to the potential receptor cross-reactivity towards closely related peptides and variable dose responsiveness seen in biological readouts.
Study Objective: To determine the dose responsiveness to nitric oxide in adult cardiac surgery patients, especially in those patients with pulmonary hypertension.
Compounds 19b, 19d and 19p displayed clear dose responsiveness in the lymphocyte reduction model when administered orally at doses of 0.3, 1.0, 3.0 mg/kg with reduced effect on heart rate.
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This implies that ligand identity, rather than cell type or downstream pathway, is the main determinant of low-dose responsiveness (Additional file 6: Figure S2G).
Since male Lrp5 −/− mice show no osteogenic response to loading in the bone cortex, and an absence of dose-responsiveness for trabecular thickness, compared with their dose-responsive WT controls, this could be ascribed to their Lrp5 status.
Dose-responsiveness between GH doses and changes of body composition was examined.
The Cmax and AUC of cotinine showed almost the same dose-responsiveness to the estimated MLE of nicotine between plasma and saliva, but the tmax and t1/2 of cotinine were not affected by the estimated MLE of nicotine in either plasma or saliva.
Dose-responsiveness was noted.
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