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As expected, NB and F-4 resulted in right shifted dose response curves relative to KU174 with NB showing minimal activity.
In a subset of 53 participants a modified relative dose response (MRDR) test was administered at home at 17 weeks of age (prior to the 17 week clinic visit).
Several distinct types of baseline gene expression data exist: tissue, cancer or development profiles (usually absolute expression values), perturbations and diseases (relative values) and time courses and dose responses (absolute or relative values), or a combination of these spatial, temporal and response profiles.
A larger group of genes were differentially expressed in human primary hepatocytes, however, little consistency was observed across compounds with respect to which genes produced a significant dose response making the determination of relative biological activity difficult.
Nevertheless, we did not observe a substantial deviation from linear associations in most studies (Supplemental Tables 2 and 3), and the estimation of trends allowed almost all studies to be included and the dose response to be compared on a relative standard scale.
Further, the stronger ORs and dose response pattern seen for multiple affected relatives suggests a role for genetic susceptibility in etiology[ 6].
The results of these experiments were used to construct relative potency plots (log dose response curves).
The authors (8) also noted a significant dose response between the number of cigarettes smoked and the relative risk of stroke.
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