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The (Fig. 8) illustrates the dose response of each individual antioxidant tested was linear, showing that reducing antioxidant activity is not concentration-dependent, at least over the concentration ranges tested in this study.
This trial was part of a novel approach to dose finding with drug combinations, in which the dose response of each component within the FDC was explored to confirm whether it is the same as the dose response when used as monotherapy.
Prior to the phase III program for the tiotropium + olodaterol FDC, a novel approach was taken to test this assumption and a series of phase II dose response trials was developed to determine the dose response of each component within the FDC.
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Dose responses of each compound were determined in order to select doses without effect alone.
From the simulation results, the microdosimetric and the absorbed dose responses of each multi-element design were consistent with the responses of the conventional single cavity detector.
Alternatively, this high dose response of maximal neutrophilic influx may be responsible for the phenomenon.
Detailed analysis showed a dose response of Ca2+ increase to different concentrations of Glu.
Fig. 1 Dose response of 223Ra (a), 188Re (b), and 99mTc (c) in the absence or presence of DMSO.
A dose response of the addition of various concentrations of N2O to the CO2 was evaluated in open surgery.
The dose response of TNF-α in mAEC was similar as detected by P-selectin and VCAM-1.
Significant discussions have been devoted to the dose response of patients to the GCase therapy.
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