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A survey of the total ionizing dose response has been carried out paying particular attention to its dependence on the layout and process choices.
An inverted U-shaped dose response has been proposed to describe the relationship between activation of mMR and mGR and changes in neuronal excitability [8].
Over and above the direct effects of alcohol on the fetus, heavy maternal consumption of alcohol during pregnancy (i.e., dose response) has been associated with PTB [ 130– 132].
An inverted U-shaped dose response has been hypothesized by Kohn and Melnick (2002) as a plausible outcome with endocrine-disrupting chemicals.
Such a paradoxical dose response has been seen for other effects of captopril, namely, the effect of this drug on drinking [ 38, 39], where captopril enhanced drinking at low doses but inhibited it at high doses.
A dose response has been observed in most series, with an increased chance of sustained local control (80 90% at 2 years) when doses >42 Gy in three fractions are used.
Similar(53)
The similar results (inverted U-shaped dose response) have been typically shown with the effects of endocrine-disrupting chemicals.
Background: The need for mechanistic understanding of nonmonotonic dose responses has been identified as one of the major data gaps in the study of bisphenol A (BPA).
He stated that virtually all of the dosing points within the selected 664 dose responses had been identified previously (Calabrese and Baldwin 2003b).
Cell cycle, apoptosis and antioxidant protection have a significant impact on the systemic end points for which non-linear dose responses have been shown.
Numerous examples of nonmonotonic dose responses have been reported for a range of EDCs and hormones at the gene expression, cell, tissue/organ, animal, and population levels (see Vandenberg et al. 2012 for a comprehensive review).
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