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All patients were treated with an adequate dose regime for several years.
In previous studies, this dose regime has been shown to be effective in decreasing microvascular permeability after burns in the rat [9, 10].
Such a dose regime avoids a substantial amount of gut induced radiation disease, and minimizes gastric distress.
Expected frequencies calculation showed that with the high dose regime statins protected 12,577 out of 14,768 patients (85.2%) without causing ADR; this value was 12,597 out of 14,625 (86.1%) in the case of the low dose regime.
None of the compounds showed any toxic effects in mice as determined by weight curves, well-being, or histology of organs following administration at a similar dose regime for over a three-week period (Figure S4, Methods S1).
The low dose regime for group 2 was epoetin delta (30 iu/Kg), while for group 3 it was equivalent dose of darbepoetin alfa (0.15 µg/Kg) and for group 4 it was epoetin beta (30 iu/Kg).
Similar(13)
Epoetin delta or darbepoetin alfa treatment of pups with OIR (treated daily P12 P16) did not influence pre-retinal neovascularisation, irrespective of low or high-dose regime.
TISOC-1 started with a split-dose regime of TPF.
Vaccination of girls & boys vs. vaccination of girls only an ICER of 28,031 €/QALY2-dosese regime) and 41,636 €/QALY3-dosese regime) is estimated.
Therefore, a sensitivity analysis with a 2-dose regime was also perfomed (cf. Table 4).
The method of corticosteroid cessation was abrupt in 37% and by a tapered reducing-dose regime in 63%.
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