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To evaluate this, the tumor-to-RBM dose ratio ADtumor/ADRBM was calculated.
A positive difference represents a higher tumor-to-RBM dose ratio in 90Y.
As expected the average 3D breast dose exceeds the average 2D dose (Ratio = 1.28).
With CUE only the 1 : 1 dose ratio comparison produced bioequivalence.
The fixed dose ratio was equivalent to 7.6 nM bortezomib 3.8 Gy X-radiation, based on their respective IC50 values.
For combinations of 131I-MIBG and bortezomib, the fixed dose ratio was 7.6 nM bortezomib:1.5 MBq 131I-MIBG.
In the animal study [5] of sumatriptan and zolmitriptan mentioned above, the dose ratio was 85/30 = 2.8.
The change of the absorbed dose ratio diamond to water with field size was around 1.3% for the three qualities.
Furthermore, based on the data of the phase I study, it was suggested that treatment with 90Y might improve the tumor-to-RBM dose ratio [11].
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In Schild regression, a plot is made of the log (dose ratio-1) versus the log concentration of antagonist for a range of antagonist concentrations.
CDR: Coughs-to-dose ratio; FEV1: Forced expiratory volume in one second; ICS: Inhaled corticosteroids; LCQ: Leicester cough questionnaire; NO: Exhaled air nitric oxide concentration; PEF: Peak expiratory flow; RDR: Response-to-dose ratio.
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