The basal glucose-lowering effect (owing to the IDeg component) was the same with OD or BID dosing because this is dependent on total dose rather than on the dosing frequency of IDegAsp.
Furthermore, paroxetine appeared the most potent with anxiolytic-like effects at a 10 mg/kg dose, rather than the 30 mg/kg doses of imipramine and fluoxetine.
Surprisingly, considering the data as a function of broadband UV dose rather than exposure time did not seem to reduce scatter.
Early trials for oligonucleotide therapeutics should consider additional endpoints for the definition of a biologically active dose rather than focusing on the traditional concept of maximal tolerated dose.
Furthermore, because skin damage depends on both the UVI and the time of exposure, that is the dose rather than the dose rate, behavioural messages should be further tailored to reflect the time needed, rather than having a simple binary message such as 'protection required' (for UVI ≥ 3) or 'no protection required' (for UVI < 3).
Dr. Robert Feig, a retina specialist in Brooklyn and the Bronx, says he wants to save patients and Medicare money by treating eye diseases with a drug that costs $50 a dose, rather than one that costs $2,000 a dose.
In engineering terms, the system "anticipates" the perturbation caused by X dose, rather than responding to an error caused by the perturbation.
But no one noticed that in her family, everyone is hyper-sensitive to statins and a small dose, rather than an average one, is all that she needed.
However, for evaluation of the effect of ionising radiation on tumour and normal tissues, absorbed dose (rather than activity concentration) is the physical quantity of interest.
The paradigm shift in cancer treatment from cytotoxic drugs to tumor targeted therapies poses new challenges, including optimization of dose and schedule based on a biologically effective dose, rather than the historical maximum tolerated dose.
As discussed before, for low implantation energies, swelling effect is predominantly dependent on implantation dose rather than implantation energy [19, 20]. Figure 1 Cross-sectional HREM images of Ge + -implanted SiN/HfO 2 /SiO 2 stack layers.
