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Acute oral toxicity study was performed according to fixed dose procedure.
The remaining alleles (220, 224, 229) cannot be assigned through the dose procedure.
Acute toxicity study of fractions was conducted as per OECD guidelines 420 (fixed dose procedure) using Swiss mice.
All the fractions were also studied for the effects of acute toxicity and behavioural changes using Swiss mice as per OECD guidelines 420 (Fixed dose procedure).
For toxicity assessment, acute toxicity study was performed according to fixed dose procedure with a single oral administration of HZJW to mice.
The acute oral toxicity study was conducted as per the OECD test guideline 420 (acute oral toxicity, fixed dose procedure) [ 16, 17].
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Preliminary results show that for high throughput/high dose procedures, lead equivalence of 0.25 mm is inadequate.
In this study, the acute oral toxicity and distribution potentials of Tween-80-coated zinc-aluminium-levodopa nanocomposite were evaluated according to the fixed dose procedures (OECD, 2002) [24].
The period of neutropenia was similar during both first and second high dose procedures, but the duration of thrombocytopenia was longer in patients receiving melphalan for a second time (median 22 16-566) dand and 41 18-699) days respectively).
Though a lesser radiation burden than digital subtraction angiography (DSA), CE-CTA is a relatively high-dose procedure, on average 13.7 mSv per study using a 4-slice scanner [36, 37].
3) Assessment of morphine potency using a within-subjects cumulative dosing procedure resulted in lower ED50 values compared to data collected using a between-subjects design (hot plate: 2.6 vs 4.9; tail withdrawal: 2.6-2.9 2.6-2.9mg/kg).
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