Fifth, a one-dose policy was recommended.
15 25 Therefore, the Expanded Programme on Immunization (EPI) recommended a one-dose policy.
The main argument advanced for a one-dose policy was that compliance with the second dose was too low.
Once again, if a single-dose policy were to be universally accepted annual savings would fall to £321,993 driving the threshold royalty fee to £6.35.
Table 3 shows the number of additional sensitisations predicted in England and Wales at different NIPD test sensitivity levels for a two-dose policy.
If a single-dose policy were to be introduced, the threshold cost would fall to £15.95 per sample, indicating that NIPD will not be cost saving even at a zero royalty fee.
57 The studies indicate that a two-dose policy providing the first dose of MV before 9 months of age is associated with major reductions in child mortality compared with the current one dose at 9-month policy.
Two MMR vaccine doses provide 66%95%% effectiveness against mumps (22, 23 ), and the 2-dose policy has reduced mumps incidence by >99% compared with incidence during the prevaccine era (24 ).
The aim of the present study was to estimate the cost savings (if any) in England and Wales for two implementation strategies compared to the current two-dose RAADP programme (and a possible future single-dose policy).
If a single-dose policy (1500iu) were to become widespread (NICE 2008), this would reduce annual RAADP costs to £2.88 million assuming similar uptake levels. 1 Based on an estimated 74,783 women receiving routine antenatal prophylaxis.
