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Planning target volume (PTV) maximum dose points were 76.5 and 76.3 Gy for DP and STD, respectively (p = 0.760).
EC = c (5,10) may be chosen, and the dose points will be allocated around both targets.
Panel a shows only dose points up to 180 Gy because after higher doses, the SC plasmid forms disappeared.
Nevertheless at the highest dose points significant amounts of OC DNA remained intact after exposure to each of the radionuclides.
The structural changes during irradiation were monitored in situ using transmission electron microscopy (TEM) and ex situ at certain dose points using Raman spectroscopy.
Because the calculation of SSB is based on the presence of L and SC plasmid conformations as described in the methods section by N SSB = Ln((1−L)/SC), Fig. 2a shows only dose points up to 180 Gy.
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Using a dose point kernel as alternative for the MC-simulation would reduce the time needed for the calculation.
Recently, more advanced methods for voxel-based dose calculation, such as Monte Carlo [18], dose point kernel [19], and local deposition methods [20], have been developed.
Figure 1 shows that at the dose point of 120 Gy for 223Ra, 188Re and 99mTc irradiation lead to similar yields of OC DNA of approximately 80%%.
Indeed, ADs may be estimated by means of several methods, such as the MIRD approach using S-values for doses at organ-level [7, 8], dose point kernel (DPK -based convolution [9–11], or Monte Carlo (MC) for DPK -basedixel-level.
The other assumption of local deposition algorithm is that the full width at half maximum (FWHM) of the point spread function (PSF) should be larger than the dose point kernel.
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