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Dose order was randomly assigned and each test was separated by 2 standard self-administration sessions to assess stability of responding.
Each subject received the same glucagon dose order assigned during screening on each study day.
Dose ordering was observed across UMEC QD doses with UMEC 125 μg QD demonstrating the greatest improvements in trough FEV1.
A clear monotonic UMEC dose response was observed with dose ordering from the lowest (15.6 μg) to highest dose (125 μg).
A dose ordering over the range of UMEC 15.6 125 μg QD doses was observed, with UMEC 125 μg showing the greatest improvement in trough FEV1.
Dose ordering was observed across QD doses for trough FVC and weighted mean FVC with UMEC 125 μg, showing the largest improvements compared with placebo.
There was a clear dose ordering of the peak FEV1 response, with the 115.2 μg dose presenting the greatest difference from placebo (248 mL).
Dose ordering was observed across QD dose regimens with UMEC 125 μg QD showing the greatest improvements in 0 24-hour weighted mean FEV1.
Participants in the ADHD group performed the go/no-go paradigm once on and once off their usual methylphenidate dose (order counterbalanced within the group).
In the main cohort, mean A1C reductions were dose ordered and apparent by week 4 and maintained thereafter (Fig. 2 A).
Dose ordering was observed across the QD regimens with UMEC 125 μg having the largest effect in both 0 12-hour and 12–24-hour weighted mean FEV1.
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