Suggestions(1)
Exact(2)
Patients were randomized 1 1 to one of two treatment groups, with two dose options available within each group.
While this assures that the marketed dosage will demonstrate its therapeutic effect in the majority of recipients, it also results in some patients experiencing side effects because lower dose options are not available.
Similar(58)
Five (42%) of the patients who discontinued treatment from Group B were receiving the 250 mg m−2 dose option during cycle 1 at the time of withdrawal.
14 15 More recently, this model was adapted to incorporate a two dose option and to explore the differential epidemiological impact of two and three dose schedules on incidence of cervical cancer.
Out of these, 12% of patients (n = 26) switched to Treatment B, which allowed them to either receive continued treatment with PP 150 mg eq. or to choose a flexible dose option (50-150 mg eq).
To extend available dosing options in the treatment of growth hormone deficiency, a comparative pharmacokinetic and pharmacodynamic phase-1 clinical study involving subcutaneous administration of growth hormone was conducted.
Two bioequivalence (BE) studies in healthy volunteers comparing new formulations of the recombinant human growth hormone (rhGH) Nutropin AQ (somatropin [rDNA origin] injection; Genentech, Inc., South San Francisco, CA) with the currently marketed formulation (5 mg/mL) were conducted to extend available dosing options.
To overcome these limitations, new IV iron preparations have been introduced, offering higher single-dose options with an acceptable side-effect profile [ 7].
Androgel packets are available in 2.5 g and 5 g dosing options.
The mechanism, efficacy, dosing options, and tolerability of risedronate are reviewed.
The model was used to explore dosing options for an investigational drug in pediatrics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com