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If a vitamin D level is below 30 ng/mL, the deficiency can be corrected by taking high doses — 50,000 IU of vitamin D as a single dose once a week for six to eight weeks.
The first drug licensed to counter osteoporosis, Fosamax, is now available generically as alendronate, which can be taken once a day or, at a higher dose, once a week.
If chemical A is administered at a dose that does not produce toxic levels in the tissue and the elimination of the chemical is essentially complete within 24 hours, repetitive exposures at the same dose once a day will not result in toxicity.
Mr. McConnell suggested that someone could even take a daily dose once a day for at least a week prior to a potential exposure (e.g., a "party" weekend) and continue daily dosing throughout the month to get good protection against the virus.
In addition, established MCF7 xenografts were treated with doxorubicin at the maximum tolerated dose once a week for three weeks.
In arthritis 12.5 mg or 25 mg of rofecoxib is given as a single dose once a day to control pain.
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To investigate the effect of MO on repeated administration in both normal and diabetic rabbits, it was administered in 50 and 100 mg/kg doses once a day for one week.
Toxicity of honokiol was evaluated in rats by intravenous administration with low-dose, middle-dose and high-dose once a day for 14 days.
The mice were then dosed once a day with intranasal formulations/solutions for 13 consecutive days.
Group 1 and 2 were dosed once a week at 11.00 a.m.
Liraglutide is dosed once a day, independent of meals, and is more effective in controlling fasting glycemia.
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