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Results further indicated that this poor outcome could be explained by lower compliance to the recommended self-care activities such as taking dose on time, dietary restrictions, and foot care.
All patients received the planned dose on time, with the exception of three patients experiencing a 1 4 weeks delay in dosing as a result of their symptomatic deterioration.
The ability to improve predictions of which patients are at risk for neutropenic complications might help to reduce the morbidity due to febrile neutropenia and increase the likelihood of delivering full chemotherapy dose on time.
American Society of Clinical Oncology ASCOO) guidelines recommend dose reduction in chemotherapy following onset of thrombocytopenia despite data showing full dose, on time, chemotherapy leads to reduced tumor burden and better overall survival [ 1- 3].
The primary endpoint of the study was feasibility, as assessed by the proportion of patients starting and finishing >80% of the planned dose on time for each component of treatment.
Successful application of the model will clearly define the patient group that should not receive growth-factor support and who can receive the full dose on time without a risk of complications.
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This prospective trial was designed to determine the safety and efficacy of full-dose, on-time chemotherapy in elderly patients with aggressive non-Hodgkin's lymphoma.
"Even though there is waning immunity... getting the five doses on time is still the best protection you can give your kid".
"An important thing to remember is the kids who do receive all five doses on time generally have milder (whooping cough) than those who are under-vaccinated or unvaccinated," Tartof told Reuters Health.
Of the people prescribed three weekly doses of penicillin, 34/63 (54%) received all three doses on time.
This high proportion of immunized children includes about 29% of all children who did not receive vaccine doses on time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com