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After an overnight fast for 10 h, all volunteers received a single dose of the three drugs with 200 mL of water.
The dose of the three subsequent injections was 30 mg/kg body weight with an interval of 2 weeks between the successive injections.
Compared with the control group, the levels of LDH and MDA were both increased (p < 0.05) with T-AOC and SOD decreasing (p < 0.05) with a high dose of the three nanomaterials in the exposed groups.
The i.p. route also ensured the internal dose of the three compounds.
In the second experiment, we examined the relationship between serum concentration and oral dose of the three chemicals.
A significantly larger group of elderly participants would receive a higher dose of the three drugs if MDRD4 was used for determination of dose.
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In the United States, by contrast, one day's dose of the two drugs costs $18, the company said.
At the 50 µM dose of the caspase-9 inhibitor, caspase-8 cleavage is almost completely abolished.
The average annual dose of the seven remaining radiologists was 50 mSv.
Daily glucocorticosteroid dose of the six AOSD patients was 5.3 ± 6.3 mg prednisolone equivalent.
This means that the total dose of the two drugs in combination simply is equal to equi-effective doses of the two drugs used alone; in other words, no total dose sparing advantages derive from using the drugs together.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com