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6 Hours of high-fidelity simulator practice have a positive, functional relationship with standardised learning outcomes as concluded by McGaghie et al. 6 The minimal decisive dose of simulation-based team training (SBTT) that can add to learning, either on its own or for later reiteration, is unknown.

The results reported here show that 5.0 μM arsenite produced a small increase (8%) in apoptosis after 60 hr of treatment, whereas a single 0.30 kJ/m dose of solar-simulation UVR produced 27% apoptosis by 24 hr and 51% by 36 hr, indicating that apoptosis increased gradually after exposure to UVR.

Simulated median AUC0 21 days for 600-mg s.c. dose was in the range of simulation value for i.v. dosing at Cycle 1 (1,241 and 1,349 mg*day/l, respectively) and was ~40% higher with this s.c. dose vs. that with i.v. administration at Cycle 7 (2,408 and 1,796 mg*day/l, respectively).

To evaluate the role of canakinumab dose, model simulations of total drug, total and free IL-1β, and the difference between baseline and predicted IL-1β concentrations were conducted for 150, 300, 600, and 900 mg given subcutaneously every 2 weeks for five doses.

We set up a full-scale Design of Simulation Experiment (DoSE) using the Discrete Element Method (DEM) to investigate the influence of various process parameters (the spray rate, the number of nozzles, the rotation rate and the drum load) on the coefficient of inter-tablet coating variation (cv,inter).

The incremental cost-effectiveness ratio was 50.000 and 68.000 euro per quality-adjusted life years for the higher and lower dose of edoxaban (Monte Carlo simulation).

This was followed by a second dose (Dose 2) using the pen device prepared as part of the Dose 1 simulation.

The goal of this study was to project separation between the treatment and control arms of these studies for measures of dialysis dose by using simulations based on 2-compartment variable-volume models.

The details of DOSE (digital organism simulation environment) had been described [ 18, 21– 23].

This study aims to develop and validate a linac-specific Geant4 Monte-Carlo (MC) model of an Elekta Agility collimator (Elekta AB, Sweden) to be used for dose distribution simulations of IMRT and VMAT procedures.

SIC was negative after workplace simulation with "prosthesis dose of powder" (Paladur®, Forestacryl®).

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