These include low blood pressure despite increasing dose of vasopressors, severe hypoxemia requiring a rapid increase in FiO2 or prone position, seizures, and patients' refusal.
Patients in both groups received 3-day postoperative antibiotics, and the volume of vaginal bleeding and the severity of abdominal pain (mild: bearable without any sedatives; moderate: bearable with a common dose of paracetamol; severe: unbearable and requiring pethidine) were recorded.
To exemplify, in oncology and palliative care, the key elements of quality mentioned by nurses and doctors were related to ethical challenges (providing strong medication to palliative patients with risk of over dose versus risk of severe pain) and the time component.
As a consequence, although dose reductions of bevacizumab were never done and only one patient had a 50% reduction of dose of chemotherapy because of severe haematologic toxicity, median dose intensity of bevacizumab and of irinotecan (considered as indicative for all the cytotoxic drugs) was reduced as compared with the planned one: 69% (range 60 92) and 78% (range 45 98), respectively.
Administration of morphine in increasing doses caused development of severe dependence, which was confirmed by observing withdrawal signs after 12 h of the last dose of morphine.
In that study, intensively treated adolescent and adult patients with duration of diabetes between 1 and 5 years and a C-peptide response to a standard mixed-meal stimulus between 0.2 and 0.5 pmol/mL had significantly lower A1C levels, daily insulin doses, and rates of severe hypoglycemia than intensively treated participants who were C-peptide nonresponders (1).
She recovered from a single dose of PIHP without severe toxicity, except a reduction in the grade 4 neutrophil counts (neutrophil count 200/μL) that was treated with recombinant G-CSF (CTCAE version 4.0) [14] on the 12th day after PIHP.
Vincristine showed antitumour effects on B16 melanoma cells, but a high dose of VCR induces severe bone marrow toxicity (Morrow et al, 1987).
Thus, while lower doses of 20 25 mg/kg STZ were sufficient to elevate blood glucose levels without impairing insulin secretion, the higher dose of STZ caused severe diabetes, as shown by increased glucose, β-OHB, triglycerides and decreased insulin concentrations.
These findings were similar to those of Bylund-Fellenius et al., who found higher mortality in GF mice than conventional mice with the same dose of DSS-induced severe colitis [ 24].
