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Grief, in its sly way, had curled up and secreted itself inside my childhood dolls Humpty and Bernina, biding its time, then felling me with a concentrated dose of loss as soon I dared lay hands on them.
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For functional analysis we consider the timing of the beginning, duration, loss of dose and loss of creatinine clearance.
To investigate gender differences in the effective dose of 50% for loss of consciousness (CP50LOC) for propofol using Diprifusor, the most commonly used target-controlled infusion system.
At 0.2 mg/kg, the pattern for parathion resembled that of the highest dose of diazinon, with loss of a few animals at the initiation of treatment, without progressive increases in mortality after PND3.
After six weeks, the 250 U dose induced loss of proteoglycan staining, focal chondrocyte disorganization, irregularity of the articular surface, and areas of cartilage matrix loss.
Upon co-transfection, increasing concentrations of HA-GUK or HA-AIP led to a dose dependent loss of PDZ-SH3 association to AIP or CARMA1 GUK, respectively.
The effect of locostatin is highly concentration-dependent; just a two-fold decrease in dose caused loss of inhibition.
Figure 4A demonstrates a time and dose dependent loss of protein expression in treated cells.
These antisense oligos target the respective mRNAs and induce a dose dependent loss of function (Nicoli et al., 2012; Villefranc et al., 2013).
Scope for lowering the steroid dose without loss of asthma control has previously been described [ 18] and the addition of an inhaled long-acting beta agonist often permits better control and use of a lower dose of inhaled steroid [ 14].
In countries where the incidence of invasive MenC disease in infancy has been controlled or practically eliminated after a routine MenC vaccination programme, two MenC infant priming doses could be reduced to a single priming dose without loss of immediate post-booster immunogenicity and without any effect on reactogenicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com