Suggestions(2)
Exact(17)
At this low dose of infection, no granulomas were formed in the lungs of H37Rv infected rats and very small (0.2 to 0.7 mm2) granulomas were observed in the lungs of HN878 infected rats (data not shown).
In response to this dose of infection, granulomas were formed in the lungs of both W4 and HN878 infected rats (Figure 2C).
Some circumstances, however, were found in infections with a noncytopathic virus in which vaccination caused disease; sensitive parameters included the genetic background of the host, the time or dose of infection, and the constituents of the vaccine.
The enduring protection observed in this study gives enough reason to postulate that if an open-ended study is carried out with low dose of infection, rBCG85C vaccine in all likelihood would show enhanced survival of guinea pigs.
TSE pathogenesis has been shown to be heavily dependent on intrinsic factors specific to the strain of the agent, the route of transmission [3] and dose of infection [4].
The highest dose of infection gave rise to well organized small granulomas that on average increased in size from about 0.6 mm2 to 1.2 mm2 from day 14 to 28 post infection.
Similar(43)
We further demonstrate that, in direct contrast to those results obtained using the flow cytometry based method of detection [11], a similar frequency of rDC (5 7%) and LNDC (1 2%) are infected in vivo following either high or low doses of infection.
Host immunity and genetics, routes and doses of infection, viral tropism, replicative capacities of strains all combine to create infections ranging from mild to lethal.
Monkeys previously infected with L. major had much smaller lesions that resolved faster compared with those of naı̈ve monkeys in response to the two higher doses of infection.
Sheep exposed to higher doses had 3.5 times greater odds to shed MAP in their faeces (assessed by faecal culture) compared to animals exposed to lower doses of infection.
The passive transfer of sera obtained from immunized mice conferred full protection of naïve unirradiated as well as sublethally irradiated mice against low lethal doses of infection with F. tularensis LVS or strain 15, in all variants of the experiments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com