Exact(1)
Whereas the doses of the other three coagulation factors in the administered PCC volume were 2 4-fold those in 15 ml kg−1 porcine FFP, the corresponding dose of FIX was 33% lower.
Similar(59)
A noninferiority trial was conducted to evaluate the efficacy of a single evening dose of fixed-combination latanoprost 50 μg/mL and timolol 0.5 mg/mL (Xalacom®; LTFC), in Chinese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) who were insufficiently controlled on β-blocker monotherapy or β-blocker-based dual therapy.
In order to determine the levels of circulating FIX achieved after a high- and low-dose of FIX protein administered for ITI-like regimens, we i.v. administered 200 or 20 IU/kg of recombinant FIX in naive haemophilia B mice (n = 4 per dose) and detected 46 and 2% of normal FIX levels, respectively, 1 h after administration.
Briefly, B-cell-depleted splenocytes were negatively selected removing B cells by B220-µbeads (Miltenyi) magnetic sorting and cultured for 5 days in the presence of increasing doses of FIX.
This study aimed to define the maximum-tolerated dose (MTD) of fixed dose rate (FDR) of gemcitabine (2′-2′-difluorodeoxycitidine) infusion with circulating haemopoietic progenitor support and to evaluate the activity of the treatment.
Moreover, in a double-masked comparison, evening dosing of fixed-combination latanoprost/timolol (Xalacom®; LTFC) was found to be at least as effective as latanoprost instilled once daily in the evening and timolol administered in both the morning and evening [ 19].
The fixed GH dose group was used as a control group for estimating a metabolic effect of the dose selection procedure in the trial by regressing the metabolic variables on the intended dose of the fixed GH dose group.
Aalbers et al. [ 19] conducted a placebo-controlled study comparing one single dose of budesonide/formoterol fixed combination against formoterol alone and against salbutamol alone.
Δ ALP, Δ LSTSDS, Δ insulin and Δ IGF-ISDS showed no significant effect, whereas Δ LVDd and to a lesser extend Δ heightSDS were even somewhat negative correlated to the intended dose of the fixed GH dose group (data not shown).
Who was this Frenchwoman who had withstood actual hardship — as opposed to the kind a dose of Dramamine can fix — to solve an ancient riddle?
The original recommended dose of MMF is fixed at 2 g/day.
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