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But even though a typical dose of contrast agent contains 90 to several hundred times the recommended daily intake of iodide, there was little research looking at its effect on the thyroid.
Increasing the dose of contrast agent or increasing the flip angle in these patients may help compensate for lower liver signal [72].
An injection of too high a dose of contrast media will have a negative effect due to the intense enhancement, potentially masking the presence of lacerations [6].
Also, the volume of injected contrast agent has to be considered and adapted; as for a visual assessment, a higher dose of contrast agent is typically recommended than for a quantitative assessment.
This dynamic acquisition can be acquired with a low dose of contrast media (a fifth of the regular dose) and also be used to calculate the bolus arrival time to properly initiate the late arterial phase of the high-resolution conventional dynamic sequence.
In fact administration of an excessive dose of contrast agent due to poor experience of the operator can affect the diagnosis: the dose depends on the target organ but also on the characteristics of the equipment used, the use of high doses of contrast agent results in excessive hyperechogenicity of the parenchyma which disturbs the identification of small traumatic injuries [7].
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In 2016, the radiochemistry team in the Center successfully produced a record 277 doses of contrast agent for human MR-PET studies.
In our experience, with a 3 6-MHz convex transducer, the use of higher doses of contrast agents does not improve the image or change the quantitative measurement.
We acknowledge that the volume of intravenous and oral contrast administered affects automated tube current modulation [6, 23] and our cohort received standard IV and oral contrast, not weight-adapted doses of contrast.
Higher doses of contrast medium provided stronger enhancement (Fig. 1).
High doses of contrast agents are required in PCI.
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