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The result of flow cytometry, with the dose of compound 9o increasing, which indicated the compound 9o could induce remarkable apoptosis of A549 and cells in a dose dependent manner.
The fact that the amplitudes of effect were even higher when the same dose of compound was combined with SSRIs clearly indicates that, in this case, the aimed "augmentation" was actually effective.
Four replicates were used for each dose of compound under study.
Only the highest dose of Compound A applied (500 nM) induced apoptosis in some CD40-stimulated CLL samples.
The ceiling dose of compound 24 was found to be 4 mg; however, prazosin has a ceiling dose of 5 mg.
For this process, two-thirds of the aquarium water was removed every 48 hr and replaced with fresh water plus a fresh dose of compound.
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This is also observed in in vivo activity test as dose for omeprazole was very higher than the dose of compounds (5a f) suggesting that these compounds are far more potent than omeprazole.
Thus, the inhibitory effect of Nec-1i might be due to the high dose of compounds reaching equipotent concentrations in target organs, which could mask the difference in the effective dose.
Additionally, combination of inactive doses of compound 17 (0.1 mg/kg) and donepezil (0.3 mg/kg) produced synergistic effect to reverse scopolamine-induced memory deficits.
Following delivery of 2 doses of compound over a 24-hr period, tumors were isolated 4 hrs after the 2nd injection.
To determine which doses of compound produce significant differences in toxicity between sensitive and resistant mites, Fisher's exact test on a single sided hypothesis test was performed in SPSS (Chatswood, NSW, Australia).
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