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The researchers also injected these mice with a large dose of bone marrow cells from a different mouse strain.
We applied the femoral head graft as a more or less standard "dose" of bone grafting material frequently applied in orthopedics.
To induce severe vascular regression in the bone marrow, both wild type (wt) and Cxcr2−/− mice were challenged with a lethal (9·5 Gy) dose of radiation and then transplanted with a radio-protective dose of bone marrow cells.
Depending on the intake route, the radiation dose of bone surfaces or colon was taken as regulatory limit for a decision if an individual is requested for person-specific monitoring [ 45].
The median annual committed equivalent radiation dose of bone surfaces was 0.36 mSv/year (maximum, 41 mSv/year), based on the uranium intake and the average uranium isotope activity ratios measured in Finnish drilled well waters (U U = 2) and dose conversion factors (U, 7.4 × 10−7 Sv/Bq; U, 7.1 × 10−7 Sv/Bq) (International Commission on Radiological Protection 1994).
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50 In ongoing phase III trials, ipilimumab (10 mg/kg) versus placebo is being evaluated in chemotherapy-naive patients with asymptomatic or minimally symptomatic mCRPC (CA184-095), and following a single dose of bone-directed RT in patients with mCRPC that have received prior docetaxel (CA184-043).
High doses of bone morphogenetic protein-2 (BMP-2) are required for effective bone regeneration.
A first course of gnocchi offered succulent doses of bone marrow but was unevenly seasoned, giving the middle of the dish a peppery burst and leaving the outer fringes bland.
Routinely, supra-physiological doses of bone morphogenetic proteins (BMPs) are applied perpetuating concerns over undesired side effects and cost of BMPs.
In the Wolf's study, pigs that received increasing doses of bone marrow mesenchymal cells (until 10×106 cells/kg) displayed improvements in cardiac function only with the higher cell doses.
Further studies are needed to improve the detection and dose evaluation of bone metastases using Ra-223 SPECT.
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