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For instance the timing of intervention, the appropriate dose of agents, the length of intervention, the routine use of available growth factors in clinical practice or not represent some of the important areas requiring further investigation.
From previous results it is known that the changes in integrin expression caused by immunosuppressive drugs or blocking antibodies depend on the target cells and on the type and even the dose of agents.
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Typically, the incubation period or survival time is indirectly proportional to the administered dose of agent.
D x 2 is similarly the dose of agent 2 (zoledronic acid) required to produce x percentage effect alone, and d2 is the dose of agent 2 required to produce the same x percentage effect in combination with d1.
Such effect was never observed when animals were inoculated with the high dose of agent and indicates that the Ln.
Skin injury by either agent alone was quantitated by the probability of tail necrosis as a function of dose of agent.
However, a pronounced effect could be observed when the footpad-infection was performed after lymphadenectomy with a very low dose of agent, i. e. the 0.001% inoculum.
The combination index (CI) was then calculated by the formula: CI = (d1/ D x 1) + (d2/ D x 2), where D x 1 is the dose of agent 1 (radiation) required to produce x percentage effect alone, and d1 is the dose of agent 1 required to produce the same x percentage effect in combination with d2.
Consequently, high doses of agents are required to induce unconsciousness, which has also a detrimental effect on autonomic depressions.
*Units and corresponding costs based on recommended dosing of agents.
First, we needed to administer relatively high doses of agents that were less cytotoxic to cancer cells.
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