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Governments, such as China's, that link financial reimbursement to the amount of drugs dispensed must abolish that perverse practice.Regulators need to do better in their monitoring and public-health surveillance, so that counterfeit or substandard drugs (containing less than the proper dose of active ingredients, for example) are not given to unwitting patients.
Instead of swallowing the dosage form to deliver a dose of active drug to the GI for absorption and distribution, inhaled drugs are administered using an inhalation device that delivers a nominal dose.
When the experiments were analyzed together, considering the treatment inoculated with Bradyrhizobium as the control, the addition of the lower dose of active compounds (0.1 mL L 1) resulted in increases of 29.0% in NN (p ≤ 0.05, Duncan's test) and of 143.5 kg ha-1 (4.8%) in grain yield (p ≤ 0.09, Duncan's test).
It may even be detrimental to clinical outcome as it may require reduction in the dose of active drugs.
Three randomised, double-blind, placebo-controlled crossover studies were performed; the effects of a single dose of active treatment was investigated in all three studies.
From stimulation day 8 onwards, treatment in both groups was continued with a daily s.c. dose of (active) rFSH up to and including the day of hCG administration.
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Rather, doses of active drug are interspersed with doses of placebo.
The higher doses of active nasal spray, either in the full study or high dose additional sample, did not produce a greater decrease in negative symptoms than the placebo nasal spray.
In spite of the fact that Algopirin® contains lower doses of active components, its effect on pain curves in migraine is superior to Excedrin®.
Placebo in this study was a rehydration treatment that appeared to be not less effective than high doses of active i.v. drugs.
Moreover, this study shows first that Indoprocaf is superior to its single active ingredients also at analgesic doses, supporting that, when used in the clinical practice, the doses of active ingredients in Indoprocaf could be lower than those of the single active ingredients when administered independently.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com