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The dose needed to be decreased from the first to the second day in five out of the seven patients, indicating that the starting dose was too high.
Patients were required to have at least one hospital blood glucose (BG) >180 mg/dL and, if on insulin, the outpatient insulin dose needed to be ≥0.5 units/kg/day.
However, while toyocamycin suppressed tumor volume to around 50% at 1 mg/kg by once-weekly injection, the STF-083010 dose needed to be 30 mg/kg by once-weekly injection.
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For activity on corn rootworm, the "1250" dose needs to be used.
There is no doubt that a few patients (fewer than 10percentt) don't feel well on methotrexate; usually the dose needs to be adjusted.
The total daily insulin dose needs to be decreased in pubertal patients but may remain unchanged in prepubertal patients.
While warfarin is generally safe and inexpensive, it takes about a week for it to become effective, and dosing is so complicated that people taking warfarin need frequent blood tests to see if the dose needs to be adjusted.
These novel results hint that a threshold dose needs to be overcome in order to observe a magnetic response in HOPG with electron-induced defects.
A patient starts on a medicine and then returns in a couple of weeks to see if the dose needs to be increased or another medicine added.
The orally administered option, Grazax, a pill placed under the tongue, must be taken once daily and only the first dose needs to be administered by a specialist.
As the total tracer dose needs to be contained in a small volume, relatively high tracer concentrations are required in the formulations for small-animal imaging.
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CEO of Professional Science Editing for Scientists @ prosciediting.com