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Nine patients (38%) required dose modification.
Eleven patients (28%) discontinued study therapy due to toxicity and 17 patients (43%) required dose modification.
The dose modification factor ranged from 2.9 after 2 h incubation to 4.5 at 6 h.
Specifically reviewed were hematologic, gastrointestinal, and renal toxicities and the need for dose modification and treatment delays.
There was no dose modification.
No dose modification was allowed.
There was no planned dose modification.
Nobody needed to have a dose modification.
Most toxicities were manageable by dose modification.
Dose modification was specified according to toxicity.
Dose modification was used to control toxicity.
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