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Although none of our exposure estimates exceeded the U. S. EPA reference dose, three participants exceeded the acceptable daily dose as defined by bench mark dose methods used by the California Office of Environmental Health Hazard Assessment.
Viral titers were estimated by optical density (at 260 nm) and median tissue culture infectious dose methods.
Improved radiation techniques at the time of patient recruitment, as well as retrieval of individual irradiation dose methods and records, allowed for proper calculations of BED.
We have developed BMDExpress, a Java application that combines traditional benchmark dose methods with gene ontology classification in the analysis of dose-response data from microarray experiments.
As new methods and tools become available, risk analysis of and time-related adverse effects will evolve beyond current rudimentary approaches, such as modifying data on no observed adverse effect level/lowest observed adverse effect level using uncertainty factors, and the more recent benchmark dose methods (Allen et al. 1994).
The finding that fibrosis persists and the overall cellularity of the lesions decreases over extended periods has been reported for bleomycin models in rodents that use both multi-hit [ 7, 11] and single dose methods [ 10, 38], but not by others using rodent models where the fibrosis resolved over 6 weeks post-injury [ 8, 9].
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Acute oral toxicity evaluation was conducted according to OECD guideline number 420 by fixed dose method [35].
A minimum dose method based on staff walking road network model was proposed for the walking-path planning in nuclear facilities.
Protein synthesis was measured in mixed gastrocnemius muscle samples in 4 week animals using the flooding dose method developed by Garlick et al. [17].
420 fixed dose method.
Analgesia dose prescribing was standardised using the WHO defined daily dose method.
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