Sentence examples for dose level administered from inspiring English sources
Inspection of the scatterplots of dose vs either AUC0 ∞ or Cmax for XR11576 revealed an increase of both parameters with the dose level administered.
The MTD was defined at the outset of the trial as the highest dose level administered where ⩽1 out of 6 subjects has a DLT.
If the dose level administered to the animals is toxic, then premature death from nonneoplastic causes may prevent some dosed animals that would have developed tumors from actually doing so.
As at the highest dose level administered in this study, 1500 mg BID continuous dosing, no patient out of six patients experienced dose-limiting toxicities within the first 21 days of treatment, the MTD was not reached in this study.
The model estimated individual clearance values for each subject using all concentrations collected at each visit, taking into account time from dose, the dose level administered, and estimated residual error that resulted from assay error, inaccurate sample time information or inaccurate dosing information.
At the highest dose level administered in this study, 1500 mg BID continuous dosing, none of the six patients experienced a DLT within the first 21 days of treatment, whereas at 1500 mg BID noncontinuous dosing, one out of six patients experienced a DLT, that is, grade 3 hypertension refractory to standard treatment.
No toxicity was noted at any of the three dose levels administered.
The treatment was generally safe and well tolerated at effective dose levels, administered over a 1-month course.
There was no evidence of dose-limiting toxicity and no dose-limiting safety issues were observed at any of the dose levels administered during the study.
The response of several of these measures of lead exposure as a function of time will be discussed for each compound at the several dose levels administered.
In this study, the tumours studied were liver metastases from colorectal cancer and patients at all dose levels administered were evaluated using DCE-MRI.
