Other models are defined by λ = λ0(1+ERR) where ERR depends only on Dϕ, the radiation dose lagged by a latency parameter ϕ.
I applied several different models, each of which used as their exposure variable the radiation dose lagged by an unknown latency.
In each case the two-phase model shows large Excess Relative Risk at 10 mSv external dose lagged by the optimal latency for the cancer.
For the analysis of the secondary end point (the onset of first symptoms of CNS tumours), the exclusion period and dose lagging were both set at 1 year.
To allow for a latent period in a radiation effect, analyses were also performed using the cumulative external dose and internal liver dose lagged by 0, 5, 10, 15 and 20 years.
To investigate the possibility that children were scanned because of a suspected cancer diagnosed later, exclusion periods during which cancer incidence was not counted and cumulative dose lagging of, both, 1 4 years were applied.
It should be noted, that the at least 6 week dosing lag in the administration of BCG prior to a glucose challenge was obligatory to see the maximal protective effect of improved blood sugar control.
Relative to the other exposure conditions, the autocorrelations were generally lower and declined more steeply across lags in animals exposed to 6 mg/kg, especially during session 30, and the analyses showed statistically significant dose × lag, F(4.79,295.58) = 3.77; p < 0.01, and dose × session × lag, F(4.26,262.63) = 3.65; p < 0.01, interaction effects.
This strain × dose × lag interaction effect was statistically significant, F(4.79,295.58) = 7.26; p < 0.001.
The analyses also showed a statistically significant sex × dose × lag interaction effect, F(4.79,295.58) = 2.81; p < 0.05.
time between a reported critical PT result and warfarin dose reduction (lag period) in the manual alert study period was 11.13 ± 7.65 days.
