Exact(16)
The dialysis dose intervention is directed by the Data Coordinating Center using urea kinetic modeling programs that analyze results from dialysis treatments to monitor adherence to the study targets, adjust suggested dialysis prescriptions, and assist in trouble-shooting problems with the delivery of dialysis.
Our study design (e.g. quercetin dose, intervention period) was similar to our earlier study.
We identified two levels of influence of transferability: dose intervention and dose response.
There were a total of six deaths during the trial; none in the medium dose intervention group, 4 in the low dose intervention group and 2 in controls (P for controls vs treatment groups combined P = 0.65).
By extension to the field of clinical research, the concept of delivery of the intervention was called the "dose intervention" [ 25].
Finally, the principle of having a precise protocol for assessment and intervention appears to influence the outcomes [ 15, 25] by moderating the dose intervention or dose response.
Similar(44)
Therefore, the occurrence of toxicities in the patients who required dose escalations (Group 1) was compared with patients who did not need dose interventions based on PK and remained at the standard dose (Group 2).
The predicted optimal schedule for a three-dose intervention over the first year of life for this specific transmission setting is to give prophylactic treatment at 3, 5 and 7 months of age.
Additionally, the previous study used younger animals, a single-dose intervention, and an earlier endpoint.
However, an annual high-dose intervention was associated with a higher risk of falls and fractures in elderly patients [ 61].
This was, however, a very low-dose intervention delivered in a different setting from our pilot program, thus making it difficult to directly compare outcomes.
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