In case of approach C where dosage omissions at steady state conditions were analysed, the dosing interval between the last and next dose administered was accordingly extended, e.g. doubled (48 h instead of 24 h) for one missing dose.
The results of this study indicate that for adults aged 18 to 60 years and elderly adults over 60 years the dosing interval between vaccinations with AS03A-adjuvanted influenza A (H1N1) 2009 vaccine could be flexible.
In the clinical trials reported to date, paclitaxel and oxaliplatin were given sequentially without any dosing interval between giving the drugs (Faivre et al, 1999; Delaloge et al, 2000; Liu et al, 2002).
According to the pharmacokinetics property [ 6, 7], it was explored it would be possible to reduce the dosing interval between each tablet to 12 h and therefore limit the treatment duration to 24 hours.
We examined the importance of dosing interval between leucovorin (LCV) and 5-fluorouracil (5-FU) on intracellular thymidylate synthase (TS) ternary complex, free TS and total TS protein levels in human MCF-7 breast and NCI H630 colon cancer cell lines.
The potential predictors for ypN status analysed in this study included age, gender, chemotherapy regimen, radiation dose, interval period between radiation and surgery, distance from anal verge, cT stage, cN stage, preCRT tumour differentiation, preCRT CEA level, postCRT CEA level, ypT stage, perineural invasion, lymphovascular invasion, and tumour regression grade.
So far, the most effective and safe dose of fibrinolytic agent administered directly into the pericardial space is unknown as well as the regiment of treatment (number of doses, intervals between doses, the most effective agent).
The dose-intervals between the different doses of isometheptene (racemate and enantiomers) ranged between 5 and 15 min, as in each case we waited with the administration of the next dose until heart rate and diastolic blood pressure had returned to baseline values.
Given the prolonged duration of PQ in brain, adverse effects should be evaluated in terms of cumulative brain concentration and duration of exposure rather than dose, number of doses, or interval between doses.
The effectiveness of PDT is influenced by multiple parameters such as the type of sensitiser, its dose, the interval between sensitiser injection and photoactivation, the incident light dose (fluence) and light dose rate (fluence rate) (Henderson et al, 2004).
