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Dose intakes of study medication were noted in the patient diaries.
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Such self medications may lead to frequent and high dose intake of analgesics and then this may also end up with analgesic over use headache and other untoward effects [49].
These parameters were used to back-calculate the most likely time for dose intake, expected to produce the observed concentration according to a standard one-compartment model.
The evaluation of uncertainty around individual dose intake times showed 90% confidence intervals extending from 49% to 202% of estimates (median).
Each opening was considered as being a single dose intake.
Nevertheless, dose escalation in selected patients may be of interest with a reduced first dose intake.
First, timing of the sampling in relation to last dose intake will influence the measured concentration.
In contrast to rodent studies, only a few dose-reponse curves but mostly high vs low dose (intake) comparisons were done.
VA dosing compliance was 98.7% in the VA+ group, for a mean VA dose intake of 35.53 mg or 394.8 μg RAEs/d per child.
The primary outcome measure was recommended by ASAS (for example, ASAS-NSAID score based on NSAID category and daily dose intake) [ 31].
The PD-NC subgroups did not significantly differ in age (P = 0.129), gender (P = 0.157), UPDRS III (P = 0.480), and levodopa equivalent daily dose intake (P = 0.292) at baseline.
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