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If peripheral neuropathy persisted between two following cycles, the oxaliplatin dose in the next cycle had to reduced by 50%.
If these complications developed after docetaxel dose adjustment, the S-1 dose in the next cycle was reduced by 20%.
If diarrhea of grade ≥3 persisted despite atropine or loperamide use, the irinotecan dose in the next cycle was reduced by 20%.
The starting dose was 10 mg TAK-438 and the decision to proceed to the next dose in the next cohort was made after review of blinded safety and pharmacokinetic data from the preceding cohort.
If pain persisted between two following cycles, oxaliplatin dose in the next cycle had to be reduced by 40% Treatment withdrawal was planned in the case of persistent neuropathy with pain (G3) after the dose reduction.
Pandemic planners may consider initially administering a single dose of adjuvanted pandemic vaccine to allow higher population coverage from limited dose supply, followed by a booster dose in the next season if the same strain is circulating.
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We found the higher dosage (DDD/1,000 inhabitants/day, DDD = defined daily dose) in the 45 64 years group.
The dose in the second half of the course was reduced in 40% of the group 2 courses.
For ART adherence, ~26% of participants reported taking every medication dose in the past month.
About three-fourths (72%) of the participants reported never skipping a dose; 12% reported missing a dose in the past week.
Anti-D Immune Globulin products, which contained up to 65 μg Hg per dose in the 1990s, were another prenatal source of thimerosal.
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