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The Egyptian president has been the butt of jokes in Arab media and the Arab blogosphere for years and the dose has increased in recent weeks.
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For instance, adult rats treated with a single 3 g/kg EtOH dose had increased CRH and AVP mRNA in the PVN, whereas chronic dietary EtOH treatment reduced the number of AVP immunoreactive neurons in that same brain region [17].
In all but a few instances the dose had increased.
At study end, the mean OROS MPH daily dose had increased significantly (p < 0.001) to 32.8 ± 12.7 and 42.0 ± 15.1 mg for children and adolescents, respectively, with no between-group difference (p = 0.579) [Table 2].
In 2011, Smid et al. reported that there were no relevant clinical differences in patients treated with variable doses of beta and/or alfa agalsidase, although both patients switching to agalsidase alfa (following a dose reduction of agalsidase beta) and those who continued on a reduced agalsidase beta dose had increased levels of lyso-Gb3 suggesting increased disease activity [ 79].
The lack of data for a possible secondary neutron doses has increased due to newly designed cyclotron rooms.
Recently, the number of drug formulations that require less frequent dosing has increased, including formulations for psychotropic drugs.
Since its introduction, implementation of PCV has become widespread; coverage (≥ 3 doses) has increased from 41% of children aged 19 – 35 months in 2002 to 73% in 2004 [ 26].
Since the introduction of various long-acting ADHD medications, interest in the efficacy profile of these compounds over the day and the possibility of once-daily dosing has increased [ 14- 18].
Penicillin use was excluded because recommended daily doses have increased over the years.
Indeed, mean methotrexate doses have increased when compared with the anchor study, 16 and studies of methotrexate-naive patients have employed much higher doses than were used in the anchor study 22 or studies published around the same time on leflunomide trials.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com